"This game will be very important, and season-defining, after the week we've had," Squillaci told Arsenal TV Online.
"The league is now extra important and it would be good to go through to the Cup semi-final on Saturday too.
"When you play against a team who is around you in the Premier League it's good to impose yourself on them, whatever the competition.
"I think a win on Saturday will give us a psychological boost. The Premier League and FA Cup are different competitions but it goes without saying that a win is a win."