Wenger revealed this morning that Wilshere would not be rushed back into action, while forward Theo Walcott is also set for more treatment on what was described as a "minor hip/groin injury" picked up training with England ahead of the San Marino World Cup qualifier.
"Wilshere's injury is not better or worse. It was an inflammation of his [ankle] bone and we had such history with him [that] we are a bit more cautious than we would be with you or with me," said Wenger.
"We deferred a little bit his rehab by one week. We gave him one more week rest because it was wise medically to do it.
"Honestly, it's very difficult [to say when he will be back]. I believe in two weeks on Sunday, that means not the next game, the game after."