Sunderland boss David Moyes says Jermain Defoe has picked up a knock.
The star striker took a kick on the calf and will be rested in the third round EFL Cup tie against QPR.
With Defoe out injured, it could mean a start for youngster Joel Asoro or Victor Anichebe, who joined on a free after deadline day.
Fabio Borini remains on the sidelines after injuring his groin last month.