The pair started on the bench for Wednesday night's 2-2 draw with Arsenal.
Ince told PaddyPower: "He did the right thing in dropping Pogba and Lukaku, they don't seem remotely interested and they're just not good enough."
"Lukaku isn't scoring goals at the moment. And when he isn't scoring goals, what is he good for? Nothing. He brings nothing to the table.
"If your main role is a striker, and you're not scoring goals for fun, then what's the point of you being on the pitch? I know his confidence is low but Mourinho needs to think about the team.
"They're in eighth place, which is disgraceful. So, it's all about getting points on the table, and if that means dropping Lukaku then that's what he should do, simple."
"When it comes to Pogba. It's just another drama, another chapter in the life of him.
"He was atrocious against Southampton and didn't deserve to be picked for a game like Arsenal. It's all well and good him moaning off the pitch, but the fact is, he's doing nothing to deserve a place in the side.
"Pogba's supposed to be world class, but he looks bang average. If he thinks his place is to come on the pitch and do stupid little flicks and tricks which lead to them losing the ball – he's an idiot.
"It doesn't matter how big your name is. No one is too big of a name to be dropped at United, or at least they shouldn't be."