Ole Gunnar Solskjaer's side travel to north London on side holding an 11-point advantage over their rivals, in a remarkable turnaround from the last time the teams met, when Jose Mourinho's men ran out 6-1 winners at Old Trafford.
"It's a great game to be involved in," Maguire told United's official website.
"We have more than enough to go there and get the three points. It's two squads that you expect to be fighting at the top end of the table. We've got ourselves into a good position and they're wanting to bridge that gap.
"I want to play in the biggest games possible against the best players; that's why I joined this club. Harry [Kane] is one of those.
"I know him from England really well. He's a top striker, one of the best in the world and he does it season after season, scores goals after goals.
"He'll be ready for battle and I'll be ready for battle. May the best man win.
"It's not just individuals; it's a team effort. As a defensive unit we've got to be strong, go there and get a clean sheet and give the team the best opportunity to win the game."