That is according to Reds legend Graeme Souness.
The two teams will face off on Saturday at Old Trafford, with the winner being able to solidify second place on the Premier League table.
The Merseyside club have never won the Premier League, while United haven't lifted the title since 2013. But Souness reckons the game still holds plenty of prestige.
"It's the biggest game in English football involving the two most successful teams who don't like each other much," he told Sky Sports.
"The recent form doesn't come into it - that's what derbies are about. Liverpool are on fire and are scoring lots of goal but that will count for nothing. Manchester United are huffing and puffing but they are digging results out. They've got resilience.
"They dig results out but that will count for nothing at the weekend."