Leeds United boss Marcelo Bielsa admitted that stars Kalvin Phillips and Liam Cooper suffered serious injury blows.
The duo were taken off the field against Brentford during a thrilling 2-2 draw at the weekend.
Leeds salvaged a point in the game through a 95th minute equalizer from striker Patrick Bamford.
"At the moment I do not know nor how long they will take to recover," the Argentine said post-game.
Cooper came off in the 14th minute of the game after an injury to his right leg following a tackle, while Phillips could not make it beyond the 55th minute with an issue he sustained shortly before half-time.