The midfielder spent his whole life and career in Turin, save for a one-season loan spell at Empoli.
“Juve have always been my family and gave me the opportunity to experience a dream come true. I have so many emotions inside me that I cannot forget," Marchisio told Sky Sport Italia.
“I have been fortunate because as well as being able to play with the Juventus jersey, I've had the opportunity to win so much.
“What remains with you are not just the trophies, but above all the human connections, the rapport with teammates, the city and the fans. I'll always carry those with me."