As the Red Devils get set to host their neighbours at Old Trafford on Saturday, former United striker Yorke suggests Jose Mourinho has a very small advantage over City's Pep Guardiola in the form of Sergio Aguero being sidelined through suspension.
"It very difficult to call this game," Yorke told Sky Sports News HQ. "Both teams are playing fantastically and both managers have made an amazing start.
"The impact Mourinho and Guardiola have had with their teams has been impressive and the players have certainly responded to them.
"Manchester United are turning around and winning games they would have lost last season. Jose has brought the winning mentality back to United.
"We know Pep is an outstanding manager, we know he's been a winner wherever he's been and he seems to have implemented that in his squad at City.
"It's very difficult to call this game at this moment in time but I feel Sergio Aguero's suspension will be a big blow for City, although they still have plenty of quality players to come in there.
"Despite that, with the game being played at Old Trafford, I just feel United have the edge over City."