Moutinho has started all of Wolves' seven competitive games so far this season.
Nuno said, “He respects himself, he rests and he's a fantastic player and other players play also.
“It's a very, very busy schedule - we have to manage that and always try and make good decisions so the team stays compact and organised.
“Moutinho is just one case among others that play two games in a row and three games in a row, then we have to decide for the next one.
“The most important thing is that the players understand that they have to really, really work hard and recover well to be able to cope with such a difficult time and such a difficult schedule."