With talks regarding a deal for Real Sociedad centre-forward Willian Jose stalling, Spurs are seeking alternatives - which include Weghorst.
Weghorst has a deal with VfL until 2023.
He said earlier this season: “As far as I'm concerned, Germany and England have always been the nicest competitions that suit me. The Premier League is great of course, I would like to experience that one time. But everything has to fit."