Ozil has been axed from both the Europa League and Premier League squads at Arsenal.
Free agent Wilshere said, "He's one of the best players I've played with.
"All I can do is comment on him as a footballer and I know what he can give, so it does make it difficult to understand.
"But I'm not in the club, I don't know what's happened. I'm sure a lot of teams in England and Europe - Mesut will be the first name on the team sheet."