Whittingham and company face Premier League bottom club Sunderland at the Stadium of Light today, with three points their sole objective.
"It's huge. It's one of the biggest games since I've been here," said midfielder Whittingham, who joined Cardiff from Aston Villa in 2007.
"Along with the cup finals and the play-off finals, it is right up there with those. If we can escape relegation it will be the biggest achievement since I've been here.
"It's always going to be a big game when you know you have to win. The atmosphere is going to be brilliant, it is going to be awesome.
"It's all well and good taking points here and there, but now it is all about winning at Sunderland. It's something we are going to try our best to do.
"We will keep going until it's mathematically impossible for us to stay up. We have to do that. But it would be horrible to lose at Sunderland, and we are not thinking about it."
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