The Hammers delivered a surprise 1-0 away victory over Spurs on Saturday thanks to a second-half goal from Antonio.
And the Englishman thinks Ajax, who will face the North Londoners in the Champions League semi-final on Tuesday, should have been taking notes of the encounter.
Asked if his strike may have given Ajax a tip on how to play Spurs, Antonio said: "Definitely. The gaffer said that we should make runs in behind them because their defence doesn't like to be facing their own goal.
"We kept getting behind their full-backs and central defenders and that's how we created the goal."