A record-breaking home crowd pushed David Moyes's side to a historic last-16, second-leg win over Sevilla last month and tickets for this evening's encounter, a first European quarter-final for 41 years, sold out in days.
After all the tumult of the move from Upton Park to Stratford and the 3-0 defeat to Burnley which saw fans storm the pitch four years ago, the London Stadium now feels like a very different place.
"Yeah it has [changed]," said West Ham defender Cresswell. "There is no beating around the bush, we've had some hard years there fighting relegation.
"I've been there at Upton Park where the atmosphere was frightening at times and it doesn't matter what team we're playing, we felt we were in a game.
"The progression the club's made over the last two years, it's kind of our fortress now and teams have found it hard to play there.
"Certainly the atmosphere against Sevilla was special, and hopefully we can replicate that again."
Hammers team-mate Antonio added: "The Sevilla game just felt like they [the fans] were sucking the ball into their net.
"Sevilla are a very composed team, play great football. But you could see it. They couldn't play, couldn't deal with the pressure and the atmosphere. The fans were all over them and then we were because the fans were pushing us."
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