Hammers boss David Moyes has decided to rest the duo as the club have already qualified for the Europa League knockout stage.
"Michail is not here, no," Moyes told a pre-match press conference.
"We chose not to bring him today, but apart from that Lukasz (Fabianski) isn't here.
"We're well aware of where we are and how we've been setting up, so we'll be strong, but we know that we've got so many big games coming up now in a busy schedule.
"I think everybody would see during the competition that we've tried to make sure we mix the players in it as much as we can.
"We've got a good squad and the players have all performed well in the competition. We do want to use them all and give them an opportunity…
"We've chosen to decide when we need players. We've got a busy week coming up next week – a full Premier League fixture list for everybody – so we want to give Mick (Antonio) a good chance of being ready for it."
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