West Ham goalkeeper Lukasz Fabianski suffered a fractured cheekbone and eye socket during Saturday's 4-0 victory over Nottingham Forest.
Fabianski was forced off during the second half following a collision with Forest centre-back Felipe.
“[He's] got a fractured cheekbone and an eye socket," Hammers manager David Moyes said. “We don't quite know whether it'll be operated on or healing itself, or a time span at the moment."
Fabianski has started every Premier League game for the Hammers this season and, while he would almost certainly have been rested for the FA Cup trip to Manchester United, the 37-year-old's experience will be a big miss for Moyes' side as they look to stave off the threat of relegation.
The Pole is due to be out of contract at the end of the season, though the club have the option of a one-year extension on his deal.
“Huge [blow] for us and obviously huge for the goalkeeper as well," Moyes added. “The stage of the career for him as well."