The Hammers already defeated United at home 3-1 earlier in the season.
Now Cresswell hopes they can do the same at Old Trafford on Saturday, when the two teams meet.
The defender said to the club's official website: "It would be special if we could complete the double over them, but we know how good a team they are and they have some fantastic players.
"But they have some tough games right now, starting with their game against Barcelona in the Champions League last night, and then us on Saturday. Hopefully we can create an upset and it would be a massive victory for us if we can do that,
"You'd be lying if you said it wasn't a good time to play them in between the two legs against Barcelona, but on the other hand they're still fighting for the Champions League spots in the Premier League so they don't want to slip up. It's certainly going to be a tough game.
"The way we played in the second half at Chelsea gives us hope that we can get a result there. We know we've got tough away games at the moment, but we're aiming to create as many chances as we can to try and win the game."