Benin international Sessegnon has been sidelined since January 20 with a groin problem while Argentine Yacob has been out since February 11 with a hamstring injury.
However, a statement on Albion's official website suggests the pair could return for the visit of the reigning champions this weekend.
"Sessegnon was left out of the last match against Fulham as a precaution after being sidelined for six weeks with a groin problem.
"Yacob also missed the 1-1 draw after suffering a hamstring problem against Chelsea, but both players will be involved in full training this week."
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