Moss awarded a foul, but did not produce a second yellow and Van Persie was allowed to remain on the pitch.
"It was a clear second yellow card," Mel said.
"I didn't speak to the referee after. There was no point, but with the red card to Van Persie, the game would have changed and been completely different."
United manager David Moyes dismissed Mel's complaints.
"Robin knew exactly what was happening. I told him. I walked over and told him that I was going to have to take him off," the United manager said.
"It was a foul (against Reid) but it was not a second booking.
"It made my job easy. He played 90 minutes for Holland in midweek and I was never going to play him for another 90 minutes today."
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