RB Leipzig have defeated Spurs 1-0 in North London to take the advantage in their Champions League last-16.
It was the German club's first ever Champions League knockout match and win.
Spurs came to life with 20 minutes to play, but they struggled to create enough chances without a genuine striker.
Speaking after the game, Spurs captain Hugo Lloris said: "I want to stay positive especially after what we saw in the last 20 minutes.
"There is a second leg and we have a chance. It's not the best result we could get."