Both players had to step in at the last minute due to the injuries and illness to first-choice pairing Laurent Koscienly and Per Mertesacker and managed to come through with the goods in the form of a clean sheet in a thoroughly entertaining 0-0 draw at the Emirates.
Chambers, in particular, had an unconvincing first half but improved in the second to help Arsenal gain a point at home.
Wenger said in his post-match conference: "Chambers and Gabriel do not have the experience of playing together, they've come in from one day into the next, but overall we didn't concede.
"Petr Cech saved us two or three times in the first half. In the second half I think we should've won the game.
"We were a bit unlucky, we lacked a bit physically and collectively to finish what we started. Our game is still not fluent enough in the final third, and that's why we didn't score. The West Ham game left a trace in our heads, and it was important tonight not to lose because you could see that was a shock for us and it was important for us to get that game out of our system."