The package, which includes food, sanitary items and sanitisers, has been sent to residents of Nkawiepanin in Atwima Nwabiagya region of the west African country.
Nkawie Government Hospital also received personal protective equipment from the donation.
Welbeck's aunt, Charlotte Adwoa Tumutuom, made the donation in person and spoke of her nephew's love for the country.
"Danny has been very concerned about how his people would survive these trying times," Tumutuom told Ghanaian news website Pulse.
"Though he has never lived here, he has a great affection for the people of Ghana, so he felt it prudent to offer some help in the very small way that he can to support the government's efforts in these times."