Cazorla was a second-half substitute for Villarreal's 1-1 draw with Hercules - his first appearance in almost two years.
He later posted to social media: "Very happy and happy to return to do what I like the most. There is a lot of work ahead but it is the first step.
"Eternally grateful to the people for the love. That's just why it was worth it to get here THANK YOU. @villarrealcf."