Victory over Shakhtar would put them within a point of qualification for next year's knockout stages with two matches still to play.
Walker believes City are better equipped for the business end of the tournament this time round than they were last season, when Liverpool beat them home and away in the last eight en route to the final.
He said: “I felt last season we had a great chance but we came up against Liverpool who were on fire and we had two 10 minutes of madness in the first leg which let it go for us.
“But we have learned from that. It was a good lesson to learn and hopefully we can take it into this campaign and come with a front foot forward."