Collins, 26, has been an inspiration since his £5million summer move from West Ham.
On Sunday he needed six stitches in a head wound during the 5-2 win over Burnley.
And ahead of tonight's FA Cup replay at home to Crystal Palace, Villa boss O'Neill said: "His stitches have started to weep a bit and it might come down to having protection.
"What happened on Sunday typifies him. He is leading through example."