Donny Van de Beek was replaced in the Manchester United starting XI moments ahead of their friendly against Real Betis.
United are facing off against the La Liga side in their second World Cup friendly as they gear up the return of Premier League football.
However, after initially naming the Dutchman in their starting XI, he was replaced minutes before kick-off by youngster Isak Hansen-Aaroen.
Van de Beek in action during the club's first friendly in Spain as United lost 4-2 to Cadiz.
United were beaten 1-0 via Nabil Fekir's winner for Betis.