However, he admits United will need to be at their best to beat Southampton.
On United's attacking talent, he told the club's website: "They are amazing.
"You know you can always have options to give the ball to play to these amazing players. You know something happens if you play the ball to them.
"I played also before, a lot, in that position and, when I came in my first year in Ajax, I was always playing in the No6 position.
"After that, we got a new coach and he put me in the No10 position because he said you make a lot of goals so it's better you play there. I can play in both positions – it doesn't matter so much for me."
On playing Ralph Hassenhutl's side, Van de Beek added: "I expect a really difficult game. I think they do really well. They are strong and play as a team.
"We need to watch for ourselves, though, and I think the most important thing is we now improve and that we show what we can do every week, not just every two or three matches, but we are consistent."