Uruguay beat Ghana but went out of the World Cup on goals scored as they finished third behind South Korea in Group H, despite Luiz Suarez's heroics.
Suarez played a major role in both of Uruguay's goals, and the 35-year-old was in tears after the final whistle, following what may have been his last international.
Both goals were scored by Giorgio de Arrascaeta - the first a close-range header, the second a sublime volley.
Uruguay's players reacted furiously at full-time, confronting the referee and appearing to manhandle an assistant after they failed to award a penalty to Darwin Nunez after a coming together with Alidu Seidu.
In Group H's other game, South Korea's 2-1 victory over group winners Portugal was enough to take them through in second place.
Uruguay and South Korea both ended with a zero goal difference, but South Korea scored four goals in their three games, while Uruguay netted twice.