The pair came through United's youth system, with Henderson now on-loan at Sheffield United.
Tuanzebe told the Manchester Evening News: "We're fortunate to have such a club that promotes youth and wants their youth to be big players and big stars in the first-team.
"Obviously we have players with the talent to do so, which we've witnessed many times this season. It's a combination of the two which breed a career.
"Dean's a big character and I'm sure when he comes back he'll just slot right back in and continue from where he left off. He's doing very well at Sheffield United and it just shows, coming from the academy, he's demonstrating what he's learnt and practising it week in, week out."