Lloris picked up a shoulder injury in last weekend's win over Manchester City and has been ruled out of Thursday's Europa League clash with La Viola and Sunday's FA Cup tie against the Eagles.
Michel Vorm will replace the Frenchman for the next two matches and Spurs manager Mauricio Pochettino has every faith in the Dutchman.
"The last action of the game against Manchester City, Hugo hurt his shoulder and is out for tomorrow and for Sunday too," Pochettino said.
"We need to assess him during the week if he can be available for next Thursday but for sure, tomorrow and next Sunday he is out.
"It is not a big, big issue; it is a very small injury. It will always impact, Hugo is our captain and it is a very important period for us.
"We know now we have a squad and we believe that Michel [Vorm] is a very good, a top goalkeeper too, and we believe in him and trust in him."