The Portuguese made 10 changes for Tottenham's Europa Conference League clash with Vitesse last week, which saw Spurs go down 1-0.
But he won't be doing the same thing against Burnley this week.
Asked whether his Premier League squad would travel to Turf Moor, Nuno said: "Basically yes, but we have players that we need, players that are working hard, maybe with the expectation that they will have more minutes, the expectation that they deserve more minutes.
"But it's up to us to manage all these situations individually, at the same time looking at which are the best partnerships for what we want to be as a team."
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