South American contingent Romero, Sanchez and Giovani Lo Celso have been training in Croatia with a Spurs coach to avoid having to self-isolate for 10 days upon their return from international duty in red-list zones last week.
The trio are due to arrive back in England on Saturday, just 24 hours before their game against Chelsea.
Their returns come at a timely moment for Nuno, whose plans in central defence are unclear heading into the weekend, says the Daily Mail.
Japhet Tanganga, who played at centre back against Crystal Palace on Saturday, is suspended following his red card at Selhurst Park.
But the potential availability of Romero and Sanchez gives Nuno options in defence.
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