Redknapp is forced to field a makeshift backline for tonight's game and will be forced to rely on his attack to shoot the north Londoners out of trouble tonight.
Yet Redknapp admits he would be even more confident if he'd had Defoe, the club's top scorer, leading the line.
He said: "With Jermain out you miss 20 goals a year for a start. He will score every other game and obviously you miss him when he doesn't play. Now it is up to other players to weigh in with goals."