The North London side will be looking to get back to winning ways when they travel to Belgian side Gent for the first leg of their last-32 Europa League tie on Thursday evening.
"After what happened against Liverpool all the players want the chance to play again and try to change the feeling," Pochettino said.
"We dropped our performance, our energy, our desire maybe … we showed that lack of competitiveness as a team and that surprised us. So maybe we will make some changes but not too many.
"I'm happy to be involved in different competitions, the Europa League and the FA Cup. It's true, it's not easy, and we need to be fresh in our minds, to take better decisions for the team. You need all the squad involved and feeling important, but I like to compete.
"Some teams, like Chelsea or Liverpool, have three or four days' holidays now to try and prepare for a week and a half for a Premier League game. But I prefer to be busy and try and win some titles. That, for me, is the best way to be."