The New York City FC striker will miss their clash with Leichtenstein due to injury.
Lopetegui said of the former Barcelona forward: “Villa's injury is a real chore.
"It's sad, but there will be more opportunities. I wasn't listening to the Bernabéu asking for Villa [to come on], I couldn't make it out. I was concentrating on the game. He came on because it was a good change."