Ward-Prowse told a press conference: "It's obviously an incredibly proud feeling for me. It's always been a life-long ambition and a career ambition to reach the senior squad.
"I think it's every young player's dream to play for England and to be given that opportunity and chance to represent your country and do everyone proud is a great honour.
"Should the chance come this week, I'll be ready to take it."
The 22-year-old, who has represented England at various youth levels - including captaining Southgate's Under-21s side, is looking forward to learning from the other players during his time with the senior side.
He added: "It's a different environment in terms of the players that you're with, but I think it's a positive thing.
"I think for me, as a young player, it is different but I'm going to use it to benefit me as a player and increase my knowledge of the game.
"I can't wait to draw every ounce of knowledge from other players who have been in the group before this week, to help me as a player as well."