Southampton defender Tino Livramento is not taking part in England's Under-21 games.
The attacking full back, who arrived from Chelsea in the summer, has been in fine form for Ralph Hasenhuttl's team this term.
However, Livramento is suffering from an injury issue that prevents him from training or playin with the Under-21s during this break.
The club confirmed the news in an official statement, while also announcing that club captain James Ward-Prowse was withdrawing from England senior duty.
The club's statement read: "Southampton captain James Ward-Prowse has been withdrawn from the latest England squad due to illness, while Tino Livramento has also been withdrawn from the England Under-21s squad due to injury."