The Egyptian has failed to score in his last six Premier League appearances.
And Bertrand hopes he can nullify the pacy winger as Saints look to extend their five-point gap from the relegation zone.
He told Sky Sports: "It's always good to play against the best players. That is why you play and it's the ultimate aim.
"I won't change my preparations. I'm just looking forward to seeing his strengths and seeing his weaknesses and trying to nullify some and exploiting the others."