The 18-year-old defender, who joined Saints as a schoolboy at under-11 level, was given a start by manager Ralph Hasenhuttl on his first appearance for the senior side.
As the youngster made his way around the side of the pitch, the travelling supporters made clear what they thought of his first efforts, chanting: “Lewis Payne, he's one of our own."
He told the club's website: “I got a message two days before and I was excited enough to even be travelling.
“Then the day before I found out I was starting. Of course there were nerves, obviously you're going to be nervous as it was a first start for the first-team and it's a big moment. But there was more excitement than nerves."
He added: “It was a dream, something you dream of as a kid hearing the fans chant you're one of their own. I came off with cramp and that was disappointing, but that made it all worth it."