Ings has played in all three Premier League matches since his loan move from Liverpool, which can be made permanent next year.
The 26-year-old endured an injury riddled time at Anfield, and Hughes has confirmed he has suffered a foot injury.
"We've got a slight concern with Danny, he's got a sore foot," Hughes said when asked about injury concerns for the trip to south London.
"We're going to have to settle that down, he hasn't been on his feet too much this week.
"We felt that was the best thing, to take the pressure off the area. Hopefully that'll allow him to be in a better place in terms of the injury.
"We're in a good place in terms of our fitness. For the most part, we're all available."