The Saints are hoping to inflict more misery on the North London club.
But after two defeats since the restart, Hasenhuttl admits the Gunners are a wounded animal that may strike back against Southampton on Thursday.
"He (Mikel Arteta) has a strong team - it's never or a good moment [to play them]," Hasenhuttl said.
"It's always difficult because they have quality, they have fantastic players and it's always to play the game.
"Even if they have a few injuries, the quality is so big they can absolutely hit back immediately and if you give them a little space, they are unstoppable with their speed.
"We must really take care, really pay attention of everything and finally make it a very good game."