The Red Devils secured second-place on the Premier League table after a 1-1 draw with Fulham.
And with the Europa League final on May 26, Solskjaer expects to rotate his squad for the visit to Molineux on Sunday.
"Yeah, there'll be some changes of course. We have to look after ourselves," said Solskjaer.
"We need to get to Poland with loads of energy and good confidence.
"We need to train well and prepare well, and let's see what we do on Sunday."