Former United boss Sir Alex Ferguson believes the club should prioritise winning the Europa League to secure a Champions League place.
United are favourites to win the one major European title they have never claimed and will take on Anderlecht in the quarter-finals.
Ferguson told ESPN: "The thing is, we've never won the Europa League. We've never won (the) UEFA Cup, what it used to be. And we've got a great draw. I'm not saying it's a certainty, but they've got a great chance.
"If you win a trophy, it's important. It doesn't matter that it's not the Champions League - it's still a European trophy. And if you win it, you get into the Champions League. The incentive is greater to do that.
"And your CV gets bigger. If we won the Europa League? Fantastic. Add it to the European Cup, the Cup Winners' Cup, the Champions League - it's bigger and bigger. We also want to be the most successful club in England."