Vardy received a second yellow card for a dive in the 2-2 draw against West Ham United on Sunday and as a result, the striker will be unavailable for the all-important encounter against Swansea City this weekend.
The loss of Vardy, which may be extended after he was charged with improper conduct by the FA, is undoubtedly a big blow for Leicester but defender Simpson is confident that the Foxes are capable of dealing with the absence of their star man.
The full-back said: "Vardy has been one of the best players in the league. But Leo came on and got a point for us, that was a lot of pressure for anyone.
"Other players have scored in the team and before last week Vards hadn't scored for five or six games, so we'll deal with it."