Wilder rejected Klopp's argument he is worried about players' welfare, insisting his main concern is helping Liverpool.
Sheffield United have consistently voted against five substitutes and Wilder says having a bigger bench makes it even harder for them.
“Cards on the table, he's going to look after his own club," said the Blades boss.
“I've got incredible respect for these top managers because they produce top results and win things.
“But they're selfish, they look after their own clubs. They're not going to be bothered about Sheffield United, they're not going to be bothered about England.
“They're going to be bothered about Liverpool, Man City and Chelsea, which I understand and respect. I would be the same, but I'm bothered about Sheffield United and it doesn't help us to have five subs.
“I don't think the common man is going to be too sympathetic to the mental aspect of players on £250,000-a-week not getting into an 18-man squad. That's bollocks as far as I'm concerned.
“My sympathy for them is not huge. If Man City are playing on a Wednesday night in Outer Mongolia and then have to play at 12.30 on a Saturday, they have to play at 12.30 on a Saturday!
"If that helps us, we'll gladly take it because this is the competitive aspect of football.
“They're not because they only look after their own club and I'm just looking after my own club."