New Granada coach Tony Adams suffered a second consecutive defeat since taking charge.
Adams saw his struggling Granada side record their second defeat since he took charge as a Ganso brace saw Sevilla take a big step towards securing the final Champions League spot following a 2-0 LaLiga victory at Ramon Sanchez Pizjuan.
Ganso netted at the start of each half and the hosts held on to move level on points with third-placed Atletico Madrid and 11 points ahead of fifth-placed Villarreal.
The home side made a bright start as Ganso picked up Stevan Jovetic's assist from the edge of the box and found the top corner from close range to hand Sevilla a fourth-minute lead.