The LaLiga will restart with the Seville derby.
"It's going to be a historic derby," Lopetegui declared in his pre-match press conference.
"The match is going to be played and we have to find a way to adapt to this context, especially as we're facing a very good opponent in Real Betis.
"There will be repercussions from this match felt around the world."
Teams have been working to a very tightly controlled schedule enforced by the Spanish government in conjunction with the health authorities, which has meant players being tested for the virus multiple times per week.
"We have been able to do very little, we have tried to train in a rigorous way by differentiating by clothing, but that is anecdotal," Lopetegui confirmed.
"The important thing is that we've been able to train.
"We have worked well through the different phases, and whilst we would all have liked more time, even discussing that is somewhat out of place, the positive aspect is that football is coming back and we all have to congratulate ourselves that this is now a reality."