While Leko will be hoping to mastermind a win against all the odds, the 42-year-old Croatian coach is preparing to realise a dream on the touchline.
He said: "I think everyone in the club and I feel very grateful to play with a coach who together with (Pep) Guardiola and (Carlo) Ancelotti, is the best coach in the 21st century, one who changed football.
"First feeling is really grateful and one of the small dreams is coming true.
"I am just super happy, you play Tottenham and Jose Mourinho, you don't get to do that every five minutes.
"Who am I to talk about Mourinho? When Mourinho was winning the Champions League, I was watching, waiting for 8.45pm to watch his games.
"I am just super happy my team plays against him. All the stories, everything about him, he just has very big respect from me, he has more trophies than some people have games.
"The most difficult thing in football is to win and Mourinho has won everywhere."