The captain, who has played a huge part in Los Blancos' success this season, has just one year left on his current deal and there is still no news over an extension.
"Ramos is going to be here for his whole life," Florentino said after the win against Villarreal.
"The fans can relax.
"He's been impressive as leader.
"The team is close and a lot of that is down to him."
"Everyone has been very good, but especially Karim," Florentino continued.
"But really, everyone has been very good.
"Sergio is the captain and more than a captain, [Thibaut] Courtois has been incredible, the coach has been the architect of everything...
"I saw on Twitter that [Zidane] has won a trophy every 19 matches [as Real Madrid boss].
"Zidane is a blessing from the sky and people can say what they want about him, we'll keep winning trophies."